The SOS response promotes qnrB quinolone‐resistance determinant expression
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چکیده
منابع مشابه
The SOS response promotes qnrB quinolone-resistance determinant expression.
The qnr genes are plasmid-borne fluoroquinolone-resistance determinants widespread in Enterobacteriaceae. Three families of qnr determinants (qnrA, B and S) have been described, but little is known about their expression and regulation. Two new determinants, qnrC and qnrD, have been found recently. Here, we describe the characterization of the qnrB2 promoter and the identification of a LexA-bin...
متن کاملSOS regulation of qnrB expression.
In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomycin C in strains with an intact lexA gene.
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Background: Biofilms predominate in nearly all nutrient-sufficient ecosystems, both natural and clinical. In clinical settings, bacteria often encounter antimicrobial and DNA damaging agents. Factual evidence shows that more and more biofilm inducing antimicrobials trigger the SOS response of bacteria. This triggering leads to a link between biofilms and SOS. The purpose of this article is to r...
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Conjugation is one mechanism for intra- and inter-species horizontal gene transfer among bacteria. Conjugative elements have been instrumental in many bacterial species to face the threat of antibiotics, by allowing them to evolve and adapt to these hostile conditions. Conjugative plasmids are transferred to plasmidless recipient cells as single-stranded DNA. We used lacZ and gfp fusions to add...
متن کاملThe SOS response controls integron recombination.
Integrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombinatio...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2009
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2009.99